{"id":9399,"date":"2025-05-26T20:00:00","date_gmt":"2025-05-26T18:00:00","guid":{"rendered":"https:\/\/ferocancer.org\/ganadores-beca-fero\/vii-projecte-fero-mango-dra-mafalda-oliveira\/"},"modified":"2025-05-26T20:00:00","modified_gmt":"2025-05-26T18:00:00","slug":"vii-projecte-fero-mango-dra-mafalda-oliveira","status":"publish","type":"ganadores-beca-fero","link":"https:\/\/ferocancer.org\/ca\/guanyadors-beca-fero\/vii-projecte-fero-mango-dra-mafalda-oliveira\/","title":{"rendered":"VII Projecte FERO-MANGO \u2013 Dra. 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Mafalda Oliveira","centro__institucion":"Vall d\u2019Hebron Institut d\u2019Oncologia (VHIO)","proyecto":"An\u00e0lisi de les modificacions immunol\u00f2giques en pacients amb c\u00e0ncer de mama triple negatiu tractades amb ter\u00e0pia neoadjuvant.","dotacion":"80.000 \u20ac","dotacion_num":"80000","descripcion":"<p>La VII Beca FERO-MANGO en c\u00e0ncer de mama, liderada per la Dra. Mafalda Oliveira del VHIO, t\u00e9 com a objectiu desenvolupar una nova eina digital per ajudar a determinar el tractament m\u00e9s adequat per a pacients amb c\u00e0ncer de mama triple negatiu preco\u00e7 (eTNBC). <\/p>\n<p>Actualment, la combinaci\u00f3 de pembrolizumab i immunoter\u00e0pia neoadjuvant (abans de la cirurgia) ha demostrat millorar els resultats en aquestes pacients, aconseguint respostes tumorals completes, una superviv\u00e8ncia lliure d\u2019esdeveniments m\u00e9s alta i una millor superviv\u00e8ncia global. Tanmateix, no totes les pacients responen igual, i algunes poden patir efectes secundaris importants. <\/p>\n<p>Aquest projecte se centra a identificar biomarcadors immunol\u00f2gics que permetin predir la resposta al tractament. Per fer-ho, s\u2019estudiaran els canvis en les c\u00e8l\u00b7lules immunit\u00e0ries, especialment en els limf\u00f2cits T, al llarg de la ter\u00e0pia. Els investigadors seguiran l\u2019evoluci\u00f3 dels clonotips del receptor de c\u00e8l\u00b7lules T (TCR) en mostres de sang i de teixit tumoral, analitzant com es relacionen aquests canvis amb l\u2019\u00e8xit del tractament.  <\/p>\n<p>L\u2019objectiu final \u00e9s crear una eina digital de suport cl\u00ednic que permeti seleccionar el tractament neoadjuvant \u00f2ptim per a cada pacient amb eTNBC. Aquesta iniciativa busca no nom\u00e9s millorar els resultats cl\u00ednics, sin\u00f3 tamb\u00e9 augmentar la qualitat de vida de les pacients, reduir efectes secundaris innecessaris i alleujar la c\u00e0rrega sobre el sistema sanitari. <\/p>\n","mostrar-aportacion":"true","texto_aportacion":"Amb l\u2019aportaci\u00f3 de MANGO","logo_aportacion":{"id":8412,"url":"https:\/\/ferocancer.org\/wp-content\/uploads\/2026\/07\/logo-mango.jpg"},"_links_to":"","_links_to_target":""},"ciudad":[148],"mes":[149],"ano":[155],"class_list":["post-9399","ganadores-beca-fero","type-ganadores-beca-fero","status-publish","has-post-thumbnail","hentry","ciudad-barcelona","mes-juny","ano-155"],"_links":{"self":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero\/9399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero"}],"about":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/types\/ganadores-beca-fero"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media\/9400"}],"wp:attachment":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media?parent=9399"}],"wp:term":[{"taxonomy":"ciudad","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ciudad?post=9399"},{"taxonomy":"mes","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/mes?post=9399"},{"taxonomy":"ano","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ano?post=9399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}