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Ana Ruiz S\u00e1enz","centro__institucion":"CICbioGUNE, Bilbao","proyecto":"Explorant el costat dol\u00e7 de les c\u00e8l\u00b7lules tumorals per optimitzar els tractaments contra el c\u00e0ncer de mama.","dotacion":"80.000\u20ac","dotacion_num":"80000","descripcion":"<p>Els anticossos conjugats a f\u00e0rmacs (ADCs) estan revolucionant el tractament dels pacients amb c\u00e0ncer de mama, per\u00f2 no tots els pacients responen de la mateixa manera. Nombrosos estudis han abordat aquest fenomen, per\u00f2 hi ha un aspecte \u00e0mpliament desconegut i que, tanmateix, pot tenir un paper fonamental en la resposta i resist\u00e8ncia a aquestes ter\u00e0pies: el recobriment de sucres de les c\u00e8l\u00b7lules tumorals. <\/p>\n<p>El laboratori liderat per la Dra. Ana Ruiz S\u00e1enz al CIC BioGUNE, a Bilbao, investigar\u00e0 com la glicosilaci\u00f3 tumoral afecta l'efic\u00e0cia d'un antic\u00f2s conjugat a f\u00e0rmac utilitzat en el tractament de c\u00e0ncer de mama HER2 positiu. Per a aix\u00f2, empraran cultius cel\u00b7lulars en 3D i models de ratol\u00ed en els quals alteraran de manera sistem\u00e0tica i controlada el patr\u00f3 de sucres a la superf\u00edcie tumoral. Aix\u00f2 els permetr\u00e0 estudiar els efectes que t\u00e9 la glicosilaci\u00f3 en l'activaci\u00f3 immunit\u00e0ria i la mort cel\u00b7lular que desencadenen els ADCs.   <\/p>\n<p>Amb els resultats del VI Projecte FERO-GHD en c\u00e0ncer de mama volen donar a con\u00e8ixer les claus de la interacci\u00f3 dels ADCs i les seves dianes terap\u00e8utiques i revelar noves vulnerabilitats en el tumor que podrien ser aprofitades terap\u00e8uticament per al benefici dels pacients amb c\u00e0ncer de mama.<\/p>\n","mostrar-aportacion":"true","texto_aportacion":"Amb l'aportaci\u00f3 de GHD","logo_aportacion":{"id":8435,"url":"https:\/\/ferocancer.org\/wp-content\/uploads\/2026\/07\/logo-ghd-3.jpg"},"_links_to":"","_links_to_target":""},"ciudad":[156],"mes":[157],"ano":[169],"class_list":["post-9413","ganadores-beca-fero","type-ganadores-beca-fero","status-publish","has-post-thumbnail","hentry","ciudad-madrid","mes-novembre","ano-169"],"_links":{"self":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero\/9413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero"}],"about":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/types\/ganadores-beca-fero"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media\/9414"}],"wp:attachment":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media?parent=9413"}],"wp:term":[{"taxonomy":"ciudad","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ciudad?post=9413"},{"taxonomy":"mes","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/mes?post=9413"},{"taxonomy":"ano","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ano?post=9413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}