{"id":9477,"date":"2022-11-15T12:00:00","date_gmt":"2022-11-15T11:00:00","guid":{"rendered":"https:\/\/ferocancer.org\/ganadores-beca-fero\/iv-projecte-fero-mango-cancer-de-mama-dra-maria-munoz-caffarel\/"},"modified":"2022-11-15T12:00:00","modified_gmt":"2022-11-15T11:00:00","slug":"iv-projecte-fero-mango-cancer-de-mama-dra-maria-munoz-caffarel","status":"publish","type":"ganadores-beca-fero","link":"https:\/\/ferocancer.org\/ca\/guanyadors-beca-fero\/iv-projecte-fero-mango-cancer-de-mama-dra-maria-munoz-caffarel\/","title":{"rendered":"IV Projecte FERO &#8211; MANGO (C\u00e0ncer de Mama) \u2013 Dra. Maria Mu\u00f1oz Caffarel"},"content":{"rendered":"","protected":false},"featured_media":9478,"template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"beca":"IV Projecte FERO - MANGO (C\u00e0ncer de Mama)","nombre":"Dra. Maria Mu\u00f1oz Caffarel","centro__institucion":"Investigadora de l'Institut d'Investigaci\u00f3 Sanit\u00e0ria Biogipuzkoa","proyecto":"IL1RAP targeting as a new therapeutic strategy for advanced triple negative breast cancer: identification of response biomarkers and mechanisims of action.","dotacion":"80.000 \u20ac","dotacion_num":"80000","descripcion":"<p>Amb l'ajuda del IV projecte FERO-Mango, l'equip de recerca de la Dra. Caffarel a l'IIS Biogipuzkoa avaluar\u00e0 el bloqueig de la prote\u00efna IL1RAP com a nova estrat\u00e8gia terap\u00e8utica per al c\u00e0ncer de mama triple negatiu avan\u00e7at. IL1RAP forma part del receptor de la interleucina 1 (IL1) i \u00e9s una prote\u00efna important en el microambient inflamatori dels tumors. La inflamaci\u00f3 cr\u00f2nica contribueix de manera important a la progressi\u00f3 tumoral i les citocines i interleucines s\u00f3n missatges que s'envien unes c\u00e8l\u00b7lules a altres i que orquestren aquest proc\u00e9s. Molts tumors depenen de la senyalitzaci\u00f3 de la citocina IL1 per al seu creixement i per desenvolupar resist\u00e8ncia a les quimioter\u00e0pies i les ter\u00e0pies dirigides. A m\u00e9s, molts tumors presenten nivells molt elevats de la prote\u00efna IL1RAP. La hip\u00f2tesi del seu projecte \u00e9s que el bloqueig d'IL1RAP pot ser una estrat\u00e8gia terap\u00e8utica efica\u00e7 per al c\u00e0ncer de mama triple negatiu avan\u00e7at en inhibir la inflamaci\u00f3 que promou el tumor. Aix\u00ed, pret\u00e9n investigar com aquesta prote\u00efna promou la progressi\u00f3 tumoral i afecta el microambient del tumor, i com els anticossos que bloquegen IL1RAP (que ja estan sent avaluats en assajos cl\u00ednics) poden impedir aquests processos.       <\/p>","mostrar-aportacion":"true","texto_aportacion":"Amb l'aportaci\u00f3 de MANGO","logo_aportacion":{"id":8412,"url":"https:\/\/ferocancer.org\/wp-content\/uploads\/2026\/07\/logo-mango.jpg"},"_links_to":"","_links_to_target":""},"ciudad":[156],"mes":[157],"ano":[177],"class_list":["post-9477","ganadores-beca-fero","type-ganadores-beca-fero","status-publish","has-post-thumbnail","hentry","ciudad-madrid","mes-novembre","ano-177"],"_links":{"self":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero\/9477","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero"}],"about":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/types\/ganadores-beca-fero"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media\/9478"}],"wp:attachment":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media?parent=9477"}],"wp:term":[{"taxonomy":"ciudad","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ciudad?post=9477"},{"taxonomy":"mes","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/mes?post=9477"},{"taxonomy":"ano","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ano?post=9477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}