{"id":9539,"date":"2019-05-15T12:00:00","date_gmt":"2019-05-15T10:00:00","guid":{"rendered":"https:\/\/ferocancer.org\/ganadores-beca-fero\/i-projecte-fero-ghd-dinvestigacio-en-cancer-de-mama-dra-violeta-serra-i-dra-judith-balmana\/"},"modified":"2019-05-15T12:00:00","modified_gmt":"2019-05-15T10:00:00","slug":"i-projecte-fero-ghd-dinvestigacio-en-cancer-de-mama-dra-violeta-serra-i-dra-judith-balmana","status":"publish","type":"ganadores-beca-fero","link":"https:\/\/ferocancer.org\/ca\/guanyadors-beca-fero\/i-projecte-fero-ghd-dinvestigacio-en-cancer-de-mama-dra-violeta-serra-i-dra-judith-balmana\/","title":{"rendered":"I Projecte FERO-GHD d&#8217;Investigaci\u00f3 en C\u00e0ncer de Mama \u2013 Dra. Violeta Serra i Dra. Judith Balma\u00f1a"},"content":{"rendered":"","protected":false},"featured_media":9540,"template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"beca":"I Projecte FERO-GHD d'Investigaci\u00f3 en C\u00e0ncer de Mama","nombre":"Dra. Violeta Serra y Dra. Judith Balma\u00f1a","centro__institucion":"Al Vall d'Hebron Institut d'Oncologia (VHIO)","proyecto":"Desenvolupament d'un test de bi\u00f2psia l\u00edquida per determinar l'estat funcional de la recombinaci\u00f3 hom\u00f2loga en portadores de la mutaci\u00f3 BRCA1\/2 en c\u00e0ncer de mama que ajudi en la selecci\u00f3 de la ter\u00e0pia.","dotacion":"80.000 \u20ac","dotacion_num":"80000","descripcion":"<p>El projecte t\u00e9 com a objectiu comprovar si la bi\u00f2psia l\u00edquida \u00e9s \u00fatil per optimitzar una prova que identifiqui els tumors m\u00e9s sensibles i monitoritzar la resposta al tractament en pacients amb c\u00e0ncer de mama i portadores d'una mutaci\u00f3 en els gens BRCA1\/2. Els tumors amb una mutaci\u00f3 en aquests gens no reparen de forma adequada certs errors de l'ADN i, per tant, s\u00f3n extremadament sensibles a un tipus de ter\u00e0pia dirigida amb inhibidors de poli (ADP-ribosa)-polimerasa (PARPi). No obstant aix\u00f2, quan el tumor evoluciona pot perdre aquesta sensibilitat. De fet, s'ha observat que el 40% dels tumors metast\u00e0tics mostren una resist\u00e8ncia intr\u00ednseca, i la majoria dels sensibles finalment progressen. La investigaci\u00f3 t\u00e9 com a objectiu desenvolupar un test de sensibilitat que es pugui utilitzar en bi\u00f2psies l\u00edquides. Amb aquest assoliment, es permetria fer seguiment de les respostes al tractament de forma longitudinal i menys invasiva que les bi\u00f2psies de tumor. Aix\u00f2 suposar\u00e0 la prescripci\u00f3 dels tractaments m\u00e9s beneficiosos per a cada pacient i reduir\u00e0 la indicaci\u00f3 d'aquells que serien inefica\u00e7os.      <\/p>","mostrar-aportacion":"true","texto_aportacion":"Finan\u00e7at gr\u00e0cies a:","logo_aportacion":{"id":8435,"url":"https:\/\/ferocancer.org\/wp-content\/uploads\/2026\/07\/logo-ghd-3.jpg"},"_links_to":"","_links_to_target":""},"ciudad":[148],"mes":[161],"ano":[187],"class_list":["post-9539","ganadores-beca-fero","type-ganadores-beca-fero","status-publish","has-post-thumbnail","hentry","ciudad-barcelona","mes-maig","ano-187"],"_links":{"self":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero\/9539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero"}],"about":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/types\/ganadores-beca-fero"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media\/9540"}],"wp:attachment":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media?parent=9539"}],"wp:term":[{"taxonomy":"ciudad","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ciudad?post=9539"},{"taxonomy":"mes","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/mes?post=9539"},{"taxonomy":"ano","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ano?post=9539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}