{"id":9557,"date":"2018-05-15T12:00:00","date_gmt":"2018-05-15T10:00:00","guid":{"rendered":"https:\/\/ferocancer.org\/ganadores-beca-fero\/xiv-beca-fero-dra-alena-gros\/"},"modified":"2018-05-15T12:00:00","modified_gmt":"2018-05-15T10:00:00","slug":"xiv-beca-fero-dra-alena-gros","status":"publish","type":"ganadores-beca-fero","link":"https:\/\/ferocancer.org\/ca\/guanyadors-beca-fero\/xiv-beca-fero-dra-alena-gros\/","title":{"rendered":"XIV Beca FERO \u2013 Dra. Alena Gros"},"content":{"rendered":"","protected":false},"featured_media":9558,"template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"beca":"XIV Beca FERO","nombre":"Dra. Alena Gros","centro__institucion":"Investigadora principal del Grup d'Immunoter\u00e0pia i Immunologia de Tumors del VHIO (Vall d\u2019Hebron Institut d'Oncologia, Barcelona)","proyecto":"Ter\u00e0pia no invasiva i personalitzada de c\u00e8l\u00b7lules T dirigida a mutacions diana recurrents.","dotacion":"80.000 \u20ac","dotacion_num":"80000","descripcion":"<p>La immunoter\u00e0pia del c\u00e0ncer aprofita el sistema immunitari, que ens protegeix d'infeccions i altres patologies, per atacar el c\u00e0ncer. Els limf\u00f2cits T s\u00f3n capa\u00e7os de recon\u00e8ixer i eliminar el tumor amb una especificitat exquisida a trav\u00e9s del reconeixement de prote\u00efnes tumorals mutades, com a conseq\u00fc\u00e8ncia de l'acumulaci\u00f3 d'alteracions gen\u00e8tiques que ocorren durant el desenvolupament tumoral. Aquests limf\u00f2cits, denominats espec\u00edfics de neoant\u00edgens, juguen un paper important en l'efic\u00e0cia de la immunoter\u00e0pia. Donada la seva capacitat d'atacar i eliminar el tumor de manera altament espec\u00edfica, l'objectiu del projecte \u00e9s desenvolupar ter\u00e0pies cel\u00b7lulars personalitzades, basades en l'administraci\u00f3 de grans nombres de limf\u00f2cits T espec\u00edfics contra neoant\u00edgens. Per a aix\u00f2, s'estudiar\u00e0 la pres\u00e8ncia de limf\u00f2cits T que reconeixen p\u00e8ptids mutats derivats de prote\u00efnes que es troben mutades de manera recurrent en c\u00e0ncer, com per exemple KRAS, en pacients amb c\u00e0ncer. Una vegada identificats, s'a\u00efllar\u00e0 el receptor de c\u00e8l\u00b7lula T, responsable de conferir especificitat antitumoral al limf\u00f2cit. Es clonar\u00e0 aquest receptor i s'introduir\u00e0 en un vector viral per induir l'expressi\u00f3 del receptor en limf\u00f2cits de sang perif\u00e8rica. D'aquesta manera, generarem un ex\u00e8rcit de limf\u00f2cits T que s\u00f3n capa\u00e7os de recon\u00e8ixer una mutaci\u00f3 espec\u00edfica de tumor. L'a\u00efllament de diversos receptors espec\u00edfics contra prote\u00efnes freq\u00fcentment mutades en c\u00e0ncer permetr\u00e0 desenvolupar ter\u00e0pies cel\u00b7lulars per tractar pacients amb malaltia metast\u00e0tica que no tenen alternatives terap\u00e8utiques.        <\/p>","mostrar-aportacion":"true","texto_aportacion":"Finan\u00e7at gr\u00e0cies a:","logo_aportacion":{"id":8371,"url":"https:\/\/ferocancer.org\/wp-content\/uploads\/2026\/07\/logo-fundacion-ramon-areces.jpg"},"_links_to":"","_links_to_target":""},"ciudad":[148],"mes":[161],"ano":[191],"class_list":["post-9557","ganadores-beca-fero","type-ganadores-beca-fero","status-publish","has-post-thumbnail","hentry","ciudad-barcelona","mes-maig","ano-191"],"_links":{"self":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero\/9557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero"}],"about":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/types\/ganadores-beca-fero"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media\/9558"}],"wp:attachment":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media?parent=9557"}],"wp:term":[{"taxonomy":"ciudad","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ciudad?post=9557"},{"taxonomy":"mes","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/mes?post=9557"},{"taxonomy":"ano","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ano?post=9557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}