{"id":9565,"date":"2018-12-15T12:00:00","date_gmt":"2018-12-15T11:00:00","guid":{"rendered":"https:\/\/ferocancer.org\/ganadores-beca-fero\/xv-beca-fero-dr-alejo-efeyan\/"},"modified":"2018-12-15T12:00:00","modified_gmt":"2018-12-15T11:00:00","slug":"xv-beca-fero-dr-alejo-efeyan","status":"publish","type":"ganadores-beca-fero","link":"https:\/\/ferocancer.org\/ca\/guanyadors-beca-fero\/xv-beca-fero-dr-alejo-efeyan\/","title":{"rendered":"XV Beca FERO \u2013 Dr. Alejo Efeyan"},"content":{"rendered":"","protected":false},"featured_media":9566,"template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"beca":"XV Beca FERO","nombre":"Dr. Alejo Efeyan","centro__institucion":"Investigador al Centre Nacional d'Investigacions Oncol\u00f2giques (CNIO)","proyecto":"Explorant depend\u00e8ncies en la senyalitzaci\u00f3 i en el metabolisme de c\u00e8l\u00b7lules B de limfomes.","dotacion":"80.000 \u20ac","dotacion_num":"80000","descripcion":"<p>Se sap que els tumors necessiten alts nivells de nutrients, per\u00f2 es desconeix quin tumor necessita quin nutrient. La present investigaci\u00f3 vol generar aquest coneixement per desenvolupar nous tractaments basats en dues estrat\u00e8gies terap\u00e8utiques complement\u00e0ries: suprimir selectivament els nutrients que els tumors necessiten per debilitar-los i, en paral\u00b7lel, evitar que els tumors notin la manca d'aquests nutrients per impedir que encenguin i apaguin els gens que els permeten adaptar-se i sobreviure en condicions de fluctuacions de nutrients. <\/p>\n<p>En limfomes en ratolins s'han identificat mutacions en gens que indiquen a la c\u00e8l\u00b7lula tumoral que certs nutrients s\u00f3n molt elevats. Aquestes mutacions fan que la c\u00e8l\u00b7lula tumoral pensi que t\u00e9 enormes quantitats d'amino\u00e0cids, per la qual cosa creix i es multiplica. S'ha vist que aquestes mutacions acceleren l'aparici\u00f3 de limfoma. En bloquejar amb un f\u00e0rmac el circuit cel\u00b7lular que connecta la detecci\u00f3 de nutrients amb la multiplicaci\u00f3 cel\u00b7lular, s'observa que la pres\u00e8ncia d'aquestes mutacions torna vulnerables les c\u00e8l\u00b7lules tumorals. El seg\u00fcent pas \u00e9s veure si aquesta debilitat existeix tamb\u00e9 en limfomes humans.    <\/p>","mostrar-aportacion":"false","texto_aportacion":"","logo_aportacion":{"id":0,"url":""},"_links_to":"","_links_to_target":""},"ciudad":[156],"mes":[190],"ano":[191],"class_list":["post-9565","ganadores-beca-fero","type-ganadores-beca-fero","status-publish","has-post-thumbnail","hentry","ciudad-madrid","mes-desembre","ano-191"],"_links":{"self":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero\/9565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero"}],"about":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/types\/ganadores-beca-fero"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media\/9566"}],"wp:attachment":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media?parent=9565"}],"wp:term":[{"taxonomy":"ciudad","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ciudad?post=9565"},{"taxonomy":"mes","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/mes?post=9565"},{"taxonomy":"ano","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ano?post=9565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}