{"id":9569,"date":"2018-12-15T12:00:00","date_gmt":"2018-12-15T11:00:00","guid":{"rendered":"https:\/\/ferocancer.org\/ganadores-beca-fero\/xv-beca-fero-dr-bruno-sainz\/"},"modified":"2018-12-15T12:00:00","modified_gmt":"2018-12-15T11:00:00","slug":"xv-beca-fero-dr-bruno-sainz","status":"publish","type":"ganadores-beca-fero","link":"https:\/\/ferocancer.org\/ca\/guanyadors-beca-fero\/xv-beca-fero-dr-bruno-sainz\/","title":{"rendered":"XV Beca FERO \u2013 Dr. Bruno Sainz"},"content":{"rendered":"","protected":false},"featured_media":9570,"template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"beca":"XV Beca FERO","nombre":"Dr. Bruno Sainz","centro__institucion":"Institut d\u2019Investigacions Biom\u00e8diques de la Universitat Aut\u00f2noma de Madrid (UAM)","proyecto":"Combatent el c\u00e0ncer de p\u00e0ncrees mitjan\u00e7ant la identificaci\u00f3 d\u2019aquells gens essencials per a la tumorig\u00e8nesi indu\u00efda per les c\u00e8l\u00b7lules mare del c\u00e0ncer.","dotacion":"80.000 \u20ac","dotacion_num":"80000","descripcion":"<p>Les c\u00e8l\u00b7lules mare del c\u00e0ncer (CSC) s\u00f3n de suma import\u00e0ncia per a la tumorigenicitat, la met\u00e0stasi i la resist\u00e8ncia terap\u00e8utica. Els impulsors d\u2019aquest projecte s\u2019han fixat tres objectius: identificar els gens responsables de l\u2019autorenovaci\u00f3 i la tumorig\u00e8nesi de les CSC pancre\u00e0tiques; validar els gens candidats en models in vivo i in vitro; provar la rellev\u00e0ncia cl\u00ednica d\u2019alterar gens candidats clau (farmacol\u00f2gicament o gen\u00e8ticament) en combinaci\u00f3 amb altres dianes en models precl\u00ednics de ratol\u00ed amb adenocarcinoma ductal pancre\u00e0tic (PDAC). <\/p>\n<p>L\u2019estudi es duu a terme mitjan\u00e7ant un enfocament gen\u00e8tic sofisticat, focalitzat i dirigit per identificar el conjunt de gens clau que determinen l\u2019estat de CSC, amb la finalitat de facilitar el desenvolupament de ter\u00e0pies personalitzades contra les CSC. Es preveu que els resultats tinguin un impacte realment important a nivell socioecon\u00f2mic, tenint en compte que el PDAC \u00e9s el m\u00e9s mortal de tots els tumors s\u00f2lids i que actualment no disposa de tractaments efectius. <\/p>","mostrar-aportacion":"false","texto_aportacion":"","logo_aportacion":{"id":0,"url":""},"_links_to":"","_links_to_target":""},"ciudad":[156],"mes":[190],"ano":[191],"class_list":["post-9569","ganadores-beca-fero","type-ganadores-beca-fero","status-publish","has-post-thumbnail","hentry","ciudad-madrid","mes-desembre","ano-191"],"_links":{"self":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero\/9569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero"}],"about":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/types\/ganadores-beca-fero"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media\/9570"}],"wp:attachment":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media?parent=9569"}],"wp:term":[{"taxonomy":"ciudad","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ciudad?post=9569"},{"taxonomy":"mes","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/mes?post=9569"},{"taxonomy":"ano","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ano?post=9569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}