{"id":9729,"date":"2013-05-15T12:00:00","date_gmt":"2013-05-15T10:00:00","guid":{"rendered":"https:\/\/ferocancer.org\/ganadores-beca-fero\/v-beca-fero-dr-yasir-ibrahim\/"},"modified":"2013-05-15T12:00:00","modified_gmt":"2013-05-15T10:00:00","slug":"v-beca-fero-dr-yasir-ibrahim","status":"publish","type":"ganadores-beca-fero","link":"https:\/\/ferocancer.org\/ca\/guanyadors-beca-fero\/v-beca-fero-dr-yasir-ibrahim\/","title":{"rendered":"V Beca FERO \u2013 Dr. Yasir Ibrahim"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"beca":"V Beca FERO","nombre":"Dr. Yasir Ibrahim","centro__institucion":"Investigador Postdoctoral del Grup de Terap\u00e8utica Experimental. VHIO (Vall d'Hebron Institut d'Oncologia, Barcelona) ","proyecto":"Estudi de biomarcadors predictius i mecanismes de resist\u00e8ncia a la ter\u00e0pia dirigida al c\u00e0ncer de mama.","dotacion":"70.000 \u20ac","dotacion_num":"70000","descripcion":"<p>Malgrat els aven\u00e7os terap\u00e8utics dels \u00faltims anys en c\u00e0ncer de mama, encara hi ha casos que es resisteixen a la ter\u00e0pia dirigida. Aquest projecte busca aprofundir en els aspectes gen\u00e8tics i moleculars que determinen la sensibilitat i la resist\u00e8ncia als medicaments m\u00e9s nous en l'actualitat en c\u00e0ncer de mama: els inhibidors de PI3K i els de CDK4\/6 en combinaci\u00f3 amb els medicaments aprovats per tractar la malaltia hormono-dependent. Amb aix\u00f2 es pret\u00e9n identificar el grup de pacients que millor es podr\u00e0 beneficiar d'aquestes ter\u00e0pies.  <\/p>\n<p>El projecte consta de tres grans potes: expansi\u00f3 del model de xenoempelt; estudi de l'activitat antitumoral dels inhibidors de PI3K i de CDK4\/6 en models derivats de c\u00e0ncer de mama PDX del subtipus luminal (ER-positiu) i HER2, mitjan\u00e7ant un assaig ex vivo; validaci\u00f3 de les associacions genotip\/marcador farmacodin\u00e0mic amb fenotip mitjan\u00e7ant t\u00e8cniques d'enginyeria gen\u00e8tica i biologia molecular.<\/p>\n","mostrar-aportacion":"true","texto_aportacion":"Patrocinador an\u00f2nim","logo_aportacion":"","_links_to":"","_links_to_target":""},"ciudad":[148],"mes":[161],"ano":[208],"class_list":["post-9729","ganadores-beca-fero","type-ganadores-beca-fero","status-publish","hentry","ciudad-barcelona","mes-maig","ano-208"],"_links":{"self":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero\/9729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ganadores-beca-fero"}],"about":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/types\/ganadores-beca-fero"}],"wp:attachment":[{"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/media?parent=9729"}],"wp:term":[{"taxonomy":"ciudad","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ciudad?post=9729"},{"taxonomy":"mes","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/mes?post=9729"},{"taxonomy":"ano","embeddable":true,"href":"https:\/\/ferocancer.org\/ca\/wp-json\/wp\/v2\/ano?post=9729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}