{"id":9541,"date":"2019-05-15T12:00:00","date_gmt":"2019-05-15T10:00:00","guid":{"rendered":"https:\/\/ferocancer.org\/ganadores-beca-fero\/1st-fero-ghd-breast-cancer-research-project-dr-violeta-serra-and-dr-judith-balmana\/"},"modified":"2019-05-15T12:00:00","modified_gmt":"2019-05-15T10:00:00","slug":"1st-fero-ghd-breast-cancer-research-project-dr-violeta-serra-and-dr-judith-balmana","status":"publish","type":"ganadores-beca-fero","link":"https:\/\/ferocancer.org\/en\/fero-grant-winners\/1st-fero-ghd-breast-cancer-research-project-dr-violeta-serra-and-dr-judith-balmana\/","title":{"rendered":"1st FERO-GHD Breast Cancer Research Project \u2013 Dr Violeta Serra and Dr Judith Balma\u00f1a"},"content":{"rendered":"","protected":false},"featured_media":9542,"template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"beca":"1st FERO-GHD Breast Cancer Research Project","nombre":"Dra. Violeta Serra y Dra. Judith Balma\u00f1a","centro__institucion":"At the Vall d\u2019Hebron Institute of Oncology (VHIO)","proyecto":"Development of a liquid biopsy test to determine the functional status of homologous recombination in BRCA1\/2 mutation carriers with breast cancer, to support therapy selection.","dotacion":"\u20ac80,000","dotacion_num":"80000","descripcion":"<p>The project aims to assess whether liquid biopsy is useful for optimising a test that identifies the most sensitive tumours and monitors response to treatment in patients with breast cancer who carry a mutation in the BRCA1\/2 genes. Tumours with a mutation in these genes do not adequately repair certain DNA errors and are therefore extremely sensitive to a type of targeted therapy with poly (ADP-ribose) polymerase inhibitors (PARPi). However, as the tumour evolves it may lose this sensitivity. In fact, it has been observed that 40% of metastatic tumours show intrinsic resistance, and most of those that are sensitive eventually progress. The research aims to develop a sensitivity test that can be used in liquid biopsies. This achievement would make it possible to monitor treatment responses longitudinally and in a less invasive way than tumour biopsies. This will enable the prescription of the most beneficial treatments for each patient and reduce the use of those that would be ineffective.      <\/p>","mostrar-aportacion":"true","texto_aportacion":"Funded thanks to:","logo_aportacion":{"id":8435,"url":"https:\/\/ferocancer.org\/wp-content\/uploads\/2026\/07\/logo-ghd-3.jpg"},"_links_to":"","_links_to_target":""},"ciudad":[151],"mes":[162],"ano":[188],"class_list":["post-9541","ganadores-beca-fero","type-ganadores-beca-fero","status-publish","has-post-thumbnail","hentry","ciudad-barcelona","mes-may","ano-188"],"_links":{"self":[{"href":"https:\/\/ferocancer.org\/en\/wp-json\/wp\/v2\/ganadores-beca-fero\/9541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ferocancer.org\/en\/wp-json\/wp\/v2\/ganadores-beca-fero"}],"about":[{"href":"https:\/\/ferocancer.org\/en\/wp-json\/wp\/v2\/types\/ganadores-beca-fero"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ferocancer.org\/en\/wp-json\/wp\/v2\/media\/9542"}],"wp:attachment":[{"href":"https:\/\/ferocancer.org\/en\/wp-json\/wp\/v2\/media?parent=9541"}],"wp:term":[{"taxonomy":"ciudad","embeddable":true,"href":"https:\/\/ferocancer.org\/en\/wp-json\/wp\/v2\/ciudad?post=9541"},{"taxonomy":"mes","embeddable":true,"href":"https:\/\/ferocancer.org\/en\/wp-json\/wp\/v2\/mes?post=9541"},{"taxonomy":"ano","embeddable":true,"href":"https:\/\/ferocancer.org\/en\/wp-json\/wp\/v2\/ano?post=9541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}