20th FERO Grant – Dr. Nicolás Herranz

His research aims to establish new therapeutic strategies for patients with advanced prostate cancer, based on the ability of some current therapies to induce senescence in cancer cells (a process of cell aging until they stop dividing, but without dying). The conversion of tumor cells into senescent cells is initially beneficial for patients because, although they remain alive, they are unable to proliferate. However, we know that if these senescent cells persist over time, they can eventually promote tumors becoming resistant to therapy and regrowing. The objective of this project is to find new drugs or combinations that neutralize senescent cells and thus prevent therapy resistance in the context of prostate cancer.