I FERO – BMS (Hemato-Oncology) – Dr. Ana Ortega-Molina

The objective of Dr. Ortega-Molina’s project is to provide new strategies for treating aggressive B-cell lymphomas, which currently show poor results with standard therapies. Diffuse large B-cell lymphoma is the most common malignant lymphoma. It consists of a heterogeneous group of tumors, some of which are fatal or have a very poor prognosis, and furthermore do not respond to current treatments. The unfolding protein response (UPR) is a cellular survival pathway induced by the accumulation of misfolded or unfolded proteins. It is known that the regulation of this pathway is altered in some tumors, especially in aggressive B-cell lymphomas; however, the consequences of these anomalies have not been characterized in detail. The project aims to understand this signaling pathway to determine the response in these types of lymphomas and elucidate vulnerabilities that could serve for the development of new therapeutic targets.